Cell Therapy Downstream Processing
Processes for downstream purification of advanced cell therapies differ dramatically from other biologics. Our cell therapy solutions can help you successfully execute the complex steps required to obtain the final cell dose within the required quality parameters.
To meet the demands of higher upstream titers and large-scale production, our downstream processing lab advances purification technologies, develops new products to enhance productivity and delivers tailored solutions to resolve customers’ downstream bottlenecks.
The downstream processing lab develops new solutions for the efficient purification of mAbs, recombinant proteins and plasmid DNA for cell and gene therapy applications. Leveraging deep expertise in a range of purification techniques, the labs also collaborate with customers to simulate their bioprocess workflows to streamline production, solve bottlenecks and identify tailored strategies to optimize the use of Avantor products.
Lab capabilities
Advanced protein purification processes
The downstream processing lab optimizes protein purification by leveraging high-throughput chromatography resins, novel ligands to enhance the efficiency of chromatography and tangential flow filtration (TFF).
These solutions help customers improve downstream productivity and achieve higher recovery rates, critical for scaling up manufacturing and accelerating the production of biologics and gene therapies with consistent quality.
Simulation of customer downstream workflows
The downstream processing lab simulates customer workflows to test and optimize Avantor products, troubleshoot customer-specific challenges and identify solutions for broader use across the industry.
Tailored downstream solutions improve the robustness and scalability of biomanufacturing processes, helping to reduce time-to-market and provide greater process consistency and quality.
Collaboration Across the Bridgwater Innovation Center
The downstream lab purifies proteins produced in the Bridgewater Innovation Center cell culture lab to validate the performance of Avantor products and drive innovations for improved productivity.
Through close collaboration with other internal labs, we continuously refine processes and foster innovation, delivering leading-edge products to customers.
Optimizing virus inactivation
Historically, virus inactivation during bioprocessing has relied on Triton X-100, a detergent now facing increasing regulatory and environmental compliance restrictions. Beyond compliance concerns, downstream yield and process efficiency can also be compromised by the extra steps required for transferring virus inactivation solutions and optimizing mixing.
To address these challenges, Avantor has developed innovative products and processes that simplify and strengthen this critical step:
- Novel viral inactivation solution – a biodegradable alternative to Triton X-100 that delivers effective virus removal while meeting regulatory and sustainability expectations.
- Avantor Magnetic Mixing System – a custom-configured platform designed to operate under diverse customer process conditions, improving consistency, reducing process time and preserving yield.
